1R55

Crystal structure of the catalytic domain of human ADAM 33

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	ADAM 33	polymer	214	23567.6	1	UniProt (Q9BZ11) Pfam (PF01421)	Homo sapiens (human)	A disintegrin and metalloproteinase domain 33
2	B (B)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G21381MC)
3	C (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	D (A)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA) PubChem (271)
5	E, F (A)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL) PubChem (312)
6	G (A)	(2S,3R)-N~4~-[(1S)-2,2-dimethyl-1-(methylcarbamoyl)propyl]-N~1~,2-dihydroxy-3-(2-methylpropyl)butanediamide	non-polymer		331.4	1	Chemie (097) PubChem (16667467) PubChem (21867770) PubChem (44342614) PubChem (58826000) PubChem (58826007) PubChem (59394878) PubChem (73014034) PubChem (73952160) PubChem (87296464) PubChem (119031) PubChem (9862390) PubChem (92402811) PubChem (92402812) PubChem (93971877) PubChem (140645509)
7	H (A)	water	water		18.0	201	Chemie (HOH)

Sequence modifications

A: 204 - 409 (UniProt: Q9BZ11)

PDB	External Database	Details
Gln 231	Asn 231	engineered mutation
Ser 410	-	cloning artifact
Gly 411	-	cloning artifact
His 412	-	expression tag
His 413	-	expression tag
His 414	-	expression tag
His 415	-	expression tag
His 416	-	expression tag
His 417	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	23567.6
Branched	Number of molecules	1
	Total formula weight	910.8
Non-Polymers*	Number of molecules	5
	Total formula weight	507.8
All*	Total formula weight	24986.2

*Water molecules are not included.