1R0P
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met in complex with the microbial alkaloid K-252a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Hepatocyte growth factor receptor | polymer | 312 | 35306.9 | 1 | UniProt (P08581) Pfam (PF07714) In PDB | Homo sapiens (human) | Met proto-oncogene tyrosine kinase, c-met, HGF receptor, HGF-SF receptor |
| 2 | A | K-252A | non-polymer | 467.5 | 1 | Chemie (KSA) | |||
| 3 | water | water | 18.0 | 201 | Chemie (HOH) |
Sequence modifications
A: 1049 - 1360 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Phe 1194 | Tyr 1194 | engineered mutation |
| Phe 1234 | Tyr 1234 | engineered mutation |
| Asp 1235 | Tyr 1235 | engineered mutation |
| Leu 1272 | Val 1272 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35306.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 467.5 | |
| All* | Total formula weight | 35774.4 |
