1R0P
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met in complex with the microbial alkaloid K-252a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hepatocyte growth factor receptor | polymer | 312 | 35306.9 | 1 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (human) | Met proto-oncogene tyrosine kinase, c-met, HGF receptor, HGF-SF receptor |
| 2 | B (A) | K-252A | non-polymer | 467.5 | 1 | Chemie (KSA) PubChem (3813) PubChem (24867866) PubChem (49868185) PubChem (3035817) PubChem (490561) PubChem (127357) PubChem (6610352) PubChem (98053103) PubChem (98118654) PubChem (101713437) PubChem (102446520) PubChem (9890741) PubChem (9912410) PubChem (9912412) PubChem (9912413) PubChem (11612445) PubChem (162981511) PubChem (144411107) PubChem (162981512) | |||
| 3 | C (A) | water | water | 18.0 | 201 | Chemie (HOH) |
Sequence modifications
A: 1049 - 1360 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Phe 1194 | Tyr 1194 | engineered mutation |
| Phe 1234 | Tyr 1234 | engineered mutation |
| Asp 1235 | Tyr 1235 | engineered mutation |
| Leu 1272 | Val 1272 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35306.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 467.5 | |
| All* | Total formula weight | 35774.4 |
