1Q8T
The Catalytic Subunit of cAMP-dependent Protein Kinase (PKA) in Complex with Rho-kinase Inhibitor Y-27632
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cAMP-dependent protein kinase, alpha-catalytic subunit | polymer | 350 | 40786.4 | 1 | UniProt (P00517) Pfam (PF00069) | Bos taurus (cattle) | PKA C-alpha, PROTEIN KINASE A |
| 2 | B (B) | cAMP-dependent protein kinase inhibitor, alpha form | polymer | 20 | 2226.4 | 1 | UniProt (P04541) UniProt (by SIFTS) (P61925) | PKI-alpha, cAMP-dependent protein kinase inhibitor, muscle/brain isoform | |
| 3 | C (A) | (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE | non-polymer | 247.3 | 1 | Chemie (Y27) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 220 | Chemie (HOH) |
Sequence modifications
A: 1 - 350 (UniProt: P00517)
| PDB | External Database | Details |
|---|---|---|
| Sep 10 | Ser 10 | modified residue |
| Tpo 197 | Thr 197 | modified residue |
| Sep 338 | Ser 338 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43012.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 247.3 | |
| All* | Total formula weight | 43260.1 |
