1Q04

Crystal structure of FGF-1, S50E/V51N

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Heparin-binding growth factor 1	polymer	146	16743.8	2	UniProt (P05230) Pfam (PF00167) In PDB	Homo sapiens (human)	Acidic fibroblast growth factor; FGF-1; HBGF-1; AFGF; Beta-endothelial cell growth factor; ECGF-beta; fibroblast growth factor 1
2	A, B	FORMIC ACID	non-polymer		46.0	4	Chemie (FMT)
3		water	water		18.0	194	Chemie (HOH)

Sequence modifications

A, B: 1 - 140 (UniProt: P05230)

PDB	External Database	Details
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
Glu 50	Ser 65	engineered mutation
Asn 51	Val 66	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33487.5
Non-Polymers*	Number of molecules	4
	Total formula weight	184.1
All*	Total formula weight	33671.6

*Water molecules are not included.