1PYW
Human class II MHC protein HLA-DR1 bound to a designed peptide related to influenza virus hemagglutinin, FVKQNA(MAA)AL, in complex with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class II histocompatibility antigen, DR alpha chain | polymer | 182 | 21155.9 | 1 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | |
| 2 | B (B) | HLA class II histocompatibility antigen, DR-1 beta chain | polymer | 190 | 22080.7 | 1 | UniProt (P13758) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P01911) | Homo sapiens (human) | |
| 3 | C (C) | 9-residue influenza virus hemagglutinin related peptide FVKQNA(MAA)AL | polymer | 10 | 1002.2 | 1 | GenBank (3212739) UniProt (by SIFTS) (P03437) | ||
| 4 | D (D) | Enterotoxin type C-3 | polymer | 239 | 27721.1 | 1 | UniProt (P23313) Pfam (PF01123) Pfam (PF02876) UniProt (by SIFTS) (P0A0L3) | Staphylococcus aureus subsp. aureus Mu50 | SEC3 |
| 5 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 414 | Chemie (HOH) |
Sequence modifications
C: 1 - 9 (GenBank: 3212739)
D: 1 - 239 (UniProt: P23313)
| PDB | External Database | Details |
|---|---|---|
| Phe 1 | Tyr 308 | engineered mutation |
| Ala 6 | Thr 313 | engineered mutation |
| Maa 7 | Leu 314 | engineered mutation |
| Ala 8 | Lys 315 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 43 | Lys 70 | engineered mutation |
| Phe 45 | Leu 72 | engineered mutation |
| Lys 46 | Ala 73 | engineered mutation |
| Trp 47 | His 74 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 71959.8 | |
| All* | Total formula weight | 71959.8 |
