1PXV
The staphostatin-staphopain complex: a forward binding inhibitor in complex with its target cysteine protease
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cysteine protease | polymer | 183 | 21062.1 | 2 | UniProt (Q70UQ8) Pfam (PF05543) UniProt (by SIFTS) (P0C1S6) | Staphylococcus aureus | |
| 2 | C, D (C, D) | cysteine protease Inhibitor | polymer | 111 | 13074.6 | 2 | UniProt (Q9EYW6) Pfam (PF09023) | Staphylococcus aureus | |
| 3 | E, F, G, H, I (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | J (B) | GUANIDINE | non-polymer | 59.1 | 1 | Chemie (GAI) | |||
| 5 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 458 | Chemie (HOH) |
Sequence modifications
A, B: 220 - 393 (UniProt: Q70UQ8)
C, D: 1 - 109 (UniProt: Q9EYW6)
| PDB | External Database | Details |
|---|---|---|
| Gly 211 | - | cloning artifact |
| His 212 | - | expression tag |
| His 213 | - | expression tag |
| His 214 | - | expression tag |
| His 215 | - | expression tag |
| His 216 | - | expression tag |
| His 217 | - | expression tag |
| Glu 218 | - | cloning artifact |
| Phe 219 | - | cloning artifact |
| Ala 243 | Cys 243 | engineered mutation |
| Ala 283 | Ser 283 | SEE REMARK 999 |
| Asn 310 | Glu 310 | SEE REMARK 999 |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | cloning artifact |
| Ser 0 | - | cloning artifact |
| Phe 70 | Ile 70 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 68273.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 539.4 | |
| All* | Total formula weight | 68812.8 |
