1PME

STRUCTURE OF PENTA MUTANT HUMAN ERK2 MAP KINASE COMPLEXED WITH A SPECIFIC INHIBITOR OF HUMAN P38 MAP KINASE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	ERK2	polymer	380	43616.1	1	UniProt (P28482) Pfam (PF00069) In PDB	Homo sapiens (human)
2	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
3	A	4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE	non-polymer		377.4	1	Chemie (SB2)
4		water	water		18.0	211	Chemie (HOH)

Sequence modifications

A: 1 - 360 (UniProt: P28482)

PDB	External Database	Details
Leu 103	Ile 103	engineered mutation
Thr 105	Gln 105	engineered mutation
His 106	Asp 106	engineered mutation
Gly 109	Glu 109	engineered mutation
Ala 110	Thr 110	engineered mutation
Cme 161	Cys 161	modified residue

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	43616.1
Non-Polymers*	Number of molecules	2
	Total formula weight	473.5
All*	Total formula weight	44089.6

*Water molecules are not included.