1PME
STRUCTURE OF PENTA MUTANT HUMAN ERK2 MAP KINASE COMPLEXED WITH A SPECIFIC INHIBITOR OF HUMAN P38 MAP KINASE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ERK2 | polymer | 380 | 43616.1 | 1 | UniProt (P28482) Pfam (PF00069) | Homo sapiens (human) | |
| 2 | B (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | C (A) | 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE | non-polymer | 377.4 | 1 | Chemie (SB2) | |||
| 4 | D (A) | water | water | 18.0 | 211 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: P28482)
| PDB | External Database | Details |
|---|---|---|
| Leu 103 | Ile 103 | engineered mutation |
| Thr 105 | Gln 105 | engineered mutation |
| His 106 | Asp 106 | engineered mutation |
| Gly 109 | Glu 109 | engineered mutation |
| Ala 110 | Thr 110 | engineered mutation |
| Cme 161 | Cys 161 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43616.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 473.5 | |
| All* | Total formula weight | 44089.6 |
