1PJ3
Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with natural substrate pyruvate, cofactor NAD+, Mn++, and allosteric activator fumarate.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | NAD-dependent malic enzyme, mitochondrial | polymer | 564 | 63893.2 | 4 | UniProt (P23368) Pfam (PF00390) Pfam (PF03949) In PDB | Homo sapiens (human) | NAD-ME, Malic enzyme 2 |
2 | A, B, C, D | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
3 | A, B, C, D | PYRUVIC ACID | non-polymer | 88.1 | 4 | Chemie (PYR) | |||
4 | A, B, C, D | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 8 | Chemie (NAD) | |||
5 | A, B, C, D | FUMARIC ACID | non-polymer | 116.1 | 4 | Chemie (FUM) | |||
6 | water | water | 18.0 | 1385 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 21 - 584 (UniProt: P23368)
PDB | External Database | Details |
---|---|---|
Mse 29 | Met 29 | modified residue |
Mse 38 | Met 38 | modified residue |
Mse 47 | Met 47 | modified residue |
Mse 75 | Met 75 | modified residue |
Mse 86 | Met 86 | modified residue |
Mse 108 | Met 108 | modified residue |
Mse 177 | Met 177 | modified residue |
Mse 219 | Met 219 | modified residue |
Mse 239 | Met 239 | modified residue |
Mse 325 | Met 325 | modified residue |
Mse 327 | Met 327 | modified residue |
Mse 343 | Met 343 | modified residue |
Mse 407 | Met 407 | modified residue |
Mse 539 | Met 539 | modified residue |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 255572.7 | |
Non-Polymers* | Number of molecules | 20 |
Total formula weight | 6343.7 | |
All* | Total formula weight | 261916.4 |