1P8V
CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Platelet glycoprotein Ib alpha chain | polymer | 279 | 31241.7 | 1 | UniProt (P07359) Pfam (PF01462) Pfam (PF13855) | Homo sapiens (human) | |
| 2 | B (B) | Prothrombin | polymer | 29 | 3432.8 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II |
| 3 | C (C) | Prothrombin | polymer | 259 | 29780.2 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II |
| 4 | D (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 5 | E (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | F (C) | DIISOPROPYL PHOSPHONATE | non-polymer | 166.2 | 1 | Chemie (DFP) | |||
| 7 | G, H, I (A, B, C) | water | water | 18.0 | 217 | Chemie (HOH) |
Sequence modifications
A: 1 - 278 (UniProt: P07359)
C: 1 - 258 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Asp 21 | Asn 37 | engineered mutation |
| Tys 276 | Tyr 292 | modified residue |
| Tys 279 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Glu 259 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 64454.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 582.6 | |
| All* | Total formula weight | 65037.3 |
