1P6A

STRUCTURAL BASIS FOR VARIATION IN ADENOVIRUS AFFINITY FOR THE CELLULAR RECEPTOR CAR (S489Y MUTANT)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Fiber protein	polymer	185	20020.6	1	UniProt (P36711) Pfam (PF00541)	Human adenovirus A serotype 12 (HAdV-12)	SPIKE, Protein IV
2	B (B)	Coxsackievirus and adenovirus receptor	polymer	124	13640.5	1	UniProt (P78310) Pfam (PF07686)	Homo sapiens (Human)	hCAR, CVB3-binding protein, Coxsackievirus B-adenovirus receptor, HCVADR

Sequence modifications

A: 403 - 587 (UniProt: P36711)

PDB	External Database	Details
Tyr 489	Ser 489	engineered mutation

B: 24 - 146 (UniProt: P78310)

PDB	External Database	Details
Gly 23	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33661.1
All*	Total formula weight	33661.1

*Water molecules are not included.