1P4R
Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bifunctional purine biosynthesis protein PURH | polymer | 592 | 64693.7 | 2 | UniProt (P31939) Pfam (PF02142) Pfam (PF01808) | Homo sapiens (human) | ATIC |
| 2 | C, G (A, B) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 3 | D, H (A, B) | AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE | non-polymer | 338.2 | 2 | Chemie (AMZ) | |||
| 4 | E, I (A, B) | N-[(S)-(4-{[(2-AMINO-4-HYDROXYQUINAZOLIN-6-YL)(DIHYDROXY)-LAMBDA~4~-SULFANYL]AMINO}PHENYL)(HYDROXY)METHYL]-L-GLUTAMIC ACID | non-polymer | 493.5 | 2 | Chemie (354) | |||
| 5 | F (A) | XANTHOSINE-5'-MONOPHOSPHATE | non-polymer | 365.2 | 1 | Chemie (XMP) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 399 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 129387.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2106.8 | |
| All* | Total formula weight | 131494.2 |
