1P4R
Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bifunctional purine biosynthesis protein PURH | polymer | 592 | 64693.7 | 2 | UniProt (P31939) Pfam (PF02142) Pfam (PF01808) | Homo sapiens (human) | ATIC |
| 2 | C, G (A, B) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) PubChem (813) | |||
| 3 | D, H (A, B) | AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE | non-polymer | 338.2 | 2 | Chemie (AMZ) PubChem (16760280) PubChem (25322835) PubChem (29971658) PubChem (29971663) PubChem (46874858) PubChem (46936194) PubChem (200) PubChem (65110) PubChem (90004537) PubChem (69015652) PubChem (92209412) PubChem (92209413) PubChem (92209414) PubChem (92209415) PubChem (159841653) PubChem (162938701) PubChem (163812830) PubChem (171699377) PubChem (173757272) | |||
| 4 | E, I (A, B) | N-[(S)-(4-{[(2-AMINO-4-HYDROXYQUINAZOLIN-6-YL)(DIHYDROXY)-LAMBDA~4~-SULFANYL]AMINO}PHENYL)(HYDROXY)METHYL]-L-GLUTAMIC ACID | non-polymer | 493.5 | 2 | Chemie (354) | |||
| 5 | F (A) | XANTHOSINE-5'-MONOPHOSPHATE | non-polymer | 365.2 | 1 | Chemie (XMP) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 399 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 129387.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2106.8 | |
| All* | Total formula weight | 131494.2 |
