1P4R

Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Bifunctional purine biosynthesis protein PURH	polymer	592	64693.7	2	UniProt (P31939) Pfam (PF02142) Pfam (PF01808) In PDB	Homo sapiens (human)	ATIC
2	A, B	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
3	A, B	AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE	non-polymer		338.2	2	Chemie (AMZ)
4	A, B	N-[(S)-(4-{[(2-AMINO-4-HYDROXYQUINAZOLIN-6-YL)(DIHYDROXY)-LAMBDA~4~-SULFANYL]AMINO}PHENYL)(HYDROXY)METHYL]-L-GLUTAMIC ACID	non-polymer		493.5	2	Chemie (354)
5	A	XANTHOSINE-5'-MONOPHOSPHATE	non-polymer		365.2	1	Chemie (XMP)
6		water	water		18.0	399	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	129387.4
Non-Polymers*	Number of molecules	7
	Total formula weight	2106.8
All*	Total formula weight	131494.2

*Water molecules are not included.