1P2Q
Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Chymotrypsinogen A | polymer | 245 | 25686.0 | 2 | UniProt (P00766) Pfam (PF00089) | Bos taurus (cattle) | |
| 2 | B, D (B, D) | Pancreatic trypsin inhibitor | polymer | 58 | 6527.5 | 2 | UniProt (P00974) Pfam (PF00014) | Bos taurus (cattle) | Basic protease inhibitor, BPI, BPTI, Aprotinin |
| 3 | E, F, G, I, J... (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 4 | H, O (A, C) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 2 | Chemie (TRS) | |||
| 5 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 499 | Chemie (HOH) |
Sequence modifications
B, D: 1 - 58 (UniProt: P00974)
| PDB | External Database | Details |
|---|---|---|
| Phe 15 | Lys 50 | engineered mutation |
| Leu 52 | Met 87 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 64427.1 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1204.9 | |
| All* | Total formula weight | 65632.0 |
