1P2K
Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Trypsinogen, cationic | polymer | 223 | 23324.3 | 1 | UniProt (P00760) Pfam (PF00089) | Bos taurus (cattle) | Beta-trypsin |
| 2 | B (I) | Pancreatic trypsin inhibitor | polymer | 58 | 6479.5 | 1 | UniProt (P00974) Pfam (PF00014) | Bos taurus (cattle) | Basic protease inhibitor, BPI, BPTI, Aprotinin |
| 3 | C (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | D, E (I) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | F, G (A, I) | water | water | 18.0 | 247 | Chemie (HOH) |
Sequence modifications
I: 1 - 58 (UniProt: P00974)
| PDB | External Database | Details |
|---|---|---|
| Val 15 | Lys 50 | engineered mutation |
| Leu 52 | Met 87 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29803.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 232.2 | |
| All* | Total formula weight | 30036.0 |
