1P1Q
Crystal structure of the GluR2 ligand binding core (S1S2J) L650T mutant in complex with AMPA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Glutamate receptor 2 | polymer | 263 | 29209.6 | 3 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Norway rat) | GluR-2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2 |
| 2 | D, F, G, I, J (A, B, C) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 3 | E, H, K (A, B, C) | (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID | non-polymer | 186.2 | 3 | Chemie (AMQ) | |||
| 4 | L, M, N (A, B, C) | water | water | 18.0 | 420 | Chemie (HOH) |
Sequence modifications
A, B, C: 3 - 117 (UniProt: P19491)
A, B, C: 120 - 263 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | cloning artifact |
| Ala 2 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Gly 118 | - | linker |
| Thr 119 | - | linker |
| Thr 138 | Leu 672 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 87628.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 885.5 | |
| All* | Total formula weight | 88514.4 |
