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Crystal Structure of the Complex of Platelet Receptor GPIb-alpha and Human alpha-Thrombin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Human Alpha Thrombin | polymer | 36 | 4096.5 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II |
| 2 | B (B) | Human Alpha Thrombin | polymer | 259 | 29780.2 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II |
| 3 | C (P) | PHE-PRO-ARG-Chloromethylketone | polymer | 3 | 419.5 | 1 | |||
| 4 | D (G) | Platelet glycoprotein Ib alpha chain precursor | polymer | 290 | 32466.9 | 1 | UniProt (P07359) Pfam (PF01462) Pfam (PF13855) | Homo sapiens (human) | Glycoprotein Ib-alpha, GP-Ib alpha, GPIbA, GPIb-alpha, CD42B, [Part of: Glycocalicin] |
| 5 | E (C) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G21381MC) | |||
| 6 | F (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | G (G) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 8 | H, I, J, K (A, B, P, G) | water | water | 18.0 | 392 | Chemie (HOH) |
Sequence modifications
G: 1 - 290 (UniProt: P07359)
| PDB | External Database | Details |
|---|---|---|
| Ala 65 | Cys 81 | engineered mutation |
| Tys 276 | Tyr 292 | modified residue |
| Tys 279 | Tyr 295 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 66763.2 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 910.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 256.7 | |
| All* | Total formula weight | 67930.7 |
