1OJO
SPECIFICITY AND MECHANISM OF STREPTOCOCCUS PNEUMONIAE HYALURONATE LYASE: COMPLEX OF THE TYR408PHE MUTANT WITH 4-SULPHATED CHONDROITIN DISACCHARIDE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HYALURONATE LYASE | polymer | 731 | 83646.1 | 1 | UniProt (Q54873) Pfam (PF08124) Pfam (PF02278) Pfam (PF02884) | STREPTOCOCCUS PNEUMONIAE | HYALURONIDASE, HYASE |
| 2 | B (B) | 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose | branched | 459.4 | 1 | In PDB GlyTouCan (G76516UK) | |||
| 3 | C, D, E, F (A) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | G (A) | water | water | 18.0 | 536 | Chemie (HOH) |
Sequence modifications
A: 168 - 892 (UniProt: Q54873)
A: 893 - 898 (PDB: 1OJO)
| PDB | External Database | Details |
|---|---|---|
| Thr 173 | Ala 290 | conflict |
| Asp 196 | Glu 313 | SEE REMARK 999 |
| Ile 223 | Thr 340 | conflict |
| Phe 408 | Tyr 525 | engineered mutation |
| Arg 496 | Cys 613 | conflict |
| Thr 541 | Pro 613 | conflict |
| Ser 704 | Gly 821 | conflict |
| Ser 736 | Phe 853 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 83646.1 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 459.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 384.3 | |
| All* | Total formula weight | 84489.7 |
