1O5F
Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Serine protease hepsin | polymer | 114 | 12522.3 | 1 | UniProt (P05981) Pfam (PF09272) | Homo sapiens (human) | Transmembrane protease, serine 1 |
| 2 | B (H) | Serine protease hepsin | polymer | 255 | 27573.1 | 1 | UniProt (P05981) Pfam (PF00089) | Homo sapiens (human) | Transmembrane protease, serine 1 |
| 3 | C (H) | 2-{5-[AMINO(IMINIO)METHYL]-6-FLUORO-1H-BENZIMIDAZOL-2-YL}-6-[(2-METHYLCYCLOHEXYL)OXY]BENZENOLATE | non-polymer | 382.4 | 1 | Chemie (CR9) | |||
| 4 | D, E (L, H) | water | water | 18.0 | 231 | Chemie (HOH) |
Sequence modifications
L: 1 - 114 (UniProt: P05981)
| PDB | External Database | Details |
|---|---|---|
| Ala 67 | Asn 112 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 40095.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 382.4 | |
| All* | Total formula weight | 40477.8 |
