1O28

Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima with FdUMP at 2.1 A resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Thymidylate synthase thyX	polymer	232	27503.7	4	UniProt (Q9WYT0) Pfam (PF02511) In PDB	Thermotoga maritima	TS, TSase, thymidylate synthase complementing protein
2	A, B, C, D	5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE	non-polymer		326.2	4	Chemie (UFP)
3	A, B, C, D	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	4	Chemie (EPE)
4	B, C, D	TRIETHYLENE GLYCOL	non-polymer		150.2	4	Chemie (PGE)
5		water	water		18.0	338	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 220 (UniProt: Q9WYT0)

PDB	External Database	Details
Met -11	-	expression tag
Gly -10	-	expression tag
Ser -9	-	expression tag
Asp -8	-	expression tag
Lys -7	-	expression tag
Ile -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	110014.7
Non-Polymers*	Number of molecules	12
	Total formula weight	2858.6
All*	Total formula weight	112873.3

*Water molecules are not included.