1NQ1
TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Thyroid hormone receptor beta-1 | polymer | 263 | 29641.3 | 1 | UniProt (P10828) Pfam (PF00104) | Homo sapiens (human) | |
| 2 | B (A) | [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID | non-polymer | 621.9 | 1 | Chemie (4HY) | |||
| 3 | C, D (A) | ARSENIC | non-polymer | 74.9 | 2 | Chemie (ARS) |
Sequence modifications
A: 202 - 461 (UniProt: P10828)
| PDB | External Database | Details |
|---|---|---|
| Ala 199 | - | cloning artifact |
| Ala 200 | - | cloning artifact |
| Met 201 | - | cloning artifact |
| Gln 243 | Arg 240 | engineered mutation |
| Asp 248 | Glu 245 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29641.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 771.8 | |
| All* | Total formula weight | 30413.0 |
