1NQ1
TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Thyroid hormone receptor beta-1 | polymer | 263 | 29641.3 | 1 | UniProt (P10828) Pfam (PF00104) In PDB | Homo sapiens (human) | |
2 | A | [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID | non-polymer | 621.9 | 1 | Chemie (4HY) | |||
3 | A | ARSENIC | non-polymer | 74.9 | 2 | Chemie (ARS) |
Sequence modifications
A: 202 - 461 (UniProt: P10828)
PDB | External Database | Details |
---|---|---|
Ala 199 | - | cloning artifact |
Ala 200 | - | cloning artifact |
Met 201 | - | cloning artifact |
Gln 243 | Arg 240 | engineered mutation |
Asp 248 | Glu 245 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 29641.3 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 771.8 | |
All* | Total formula weight | 30413.0 |