1NN1
Crystal structure of human thymidylate kinase with ddTMP and AppNHp
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | similar to THYMIDYLATE KINASE (DTMP KINASE) | polymer | 215 | 24052.5 | 1 | UniProt (P23919) Pfam (PF02223) | Homo sapiens (human) | |
| 2 | B, C (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D (A) | 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE | non-polymer | 306.2 | 1 | Chemie (2DT) | |||
| 4 | E (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 5 | F (A) | water | water | 18.0 | 280 | Chemie (HOH) |
Sequence modifications
A: 1 - 212 (UniProt: P23919)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | cloning artifact |
| Ser -1 | - | cloning artifact |
| His 0 | - | cloning artifact |
| Ala 200 | Arg 200 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24052.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 861.0 | |
| All* | Total formula weight | 24913.5 |
