1N9A
Farnesyltransferase complex with tetrahydropyridine inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein farnesyltransferase alpha subunit | polymer | 315 | 38016.7 | 1 | UniProt (Q04631) Pfam (PF01239) | Rattus norvegicus (Norway rat) | CAAX farnesyltransferase alpha subunit, RAS proteins prenyltransferase alpha, FTase-alpha |
| 2 | B (B) | Protein farnesyltransferase beta subunit | polymer | 402 | 44976.4 | 1 | UniProt (Q02293) Pfam (PF00432) | Rattus norvegicus (Norway rat) | CAAX farnesyltransferase beta subunit, RAS proteins prenyltransferase beta, FTase-beta |
| 3 | C (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (B) | ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID | non-polymer | 308.4 | 1 | Chemie (HFP) | |||
| 5 | E (B) | 1-{2-[3-(4-CYANO-BENZYL)-3H-IMIDAZOL-4-YL]-ACETYL}-5-NAPHTHALEN-1-YL-1,2,3,6-TETRAHYDRO-PYRIDINE-4-CARBONITRILE | non-polymer | 457.5 | 1 | Chemie (FTI) |
Sequence modifications
A: 55 - 369 (UniProt: Q04631)
| PDB | External Database | Details |
|---|---|---|
| Thr 156 | Ile 156 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 82993.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 831.3 | |
| All* | Total formula weight | 83824.5 |
