1N6B

Microsomal Cytochrome P450 2C5/3LVdH Complex with a dimethyl derivative of sulfaphenazole

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cytochrome P450 2C5	polymer	473	53884.3	1	UniProt (P00179) Pfam (PF00067) In PDB	Oryctolagus cuniculus (rabbit)	CYPIIC5, P450 1, Progesterone 21-hydroxylase, P450IIC5
2	A	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	A	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	1	Chemie (HEM)
4	A	4-METHYL-N-METHYL-N-(2-PHENYL-2H-PYRAZOL-3-YL)BENZENESULFONAMIDE	non-polymer		327.4	1	Chemie (DMZ)
5		water	water		18.0	118	Chemie (HOH)

Sequence modifications

A: 27 - 487 (UniProt: P00179)

PDB	External Database	Details
Met 19	-	engineered mutation
Ala 20	-	engineered mutation
Lys 21	-	engineered mutation
Lys 22	-	engineered mutation
Thr 23	-	engineered mutation
Ser 24	-	engineered mutation
Ser 25	-	engineered mutation
Lys 26	-	engineered mutation
His 202	Asn 202	engineered mutation
Glu 206	Arg 206	engineered mutation
Leu 207	Ile 207	engineered mutation
Gly 209	Ser 209	engineered mutation
Thr 210	Ser 210	engineered mutation
His 488	-	expression tag
His 489	-	expression tag
His 490	-	expression tag
His 491	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	53884.3
Non-Polymers*	Number of molecules	4
	Total formula weight	1136.0
All*	Total formula weight	55020.3

*Water molecules are not included.