1N49
Viability of a Drug-Resistant HIV-1 Protease Variant: Structural Insights for Better Anti-Viral Therapy
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Protease | polymer | 99 | 10772.7 | 4 | UniProt (P03369) Pfam (PF00077) | Human immunodeficiency virus 1 | Retropepsin |
| 2 | E, F (B, D) | RITONAVIR | non-polymer | 720.9 | 2 | BIRD (PRD_001001) Chemie (RIT) PubChem (5076) PubChem (60954) PubChem (392622) PubChem (10395099) PubChem (44325718) PubChem (45266310) PubChem (16760215) PubChem (455315) PubChem (92402731) PubChem (93535511) PubChem (93535509) PubChem (53487909) PubChem (54103495) PubChem (9853294) PubChem (135172324) PubChem (58662536) PubChem (66509020) PubChem (72942039) PubChem (72942040) PubChem (90717239) PubChem (93535510) PubChem (123133890) PubChem (133662525) PubChem (134602828) PubChem (134751724) PubChem (141861627) PubChem (169446189) PubChem (169446190) PubChem (170130299) | |||
| 3 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 99 (UniProt: P03369)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 63 | engineered mutation |
| Asn 25 | Asp 81 | engineered mutation |
| Ala 82 | Val 138 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43090.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1441.9 | |
| All* | Total formula weight | 44532.8 |
