1N49
Viability of a Drug-Resistant HIV-1 Protease Variant: Structural Insights for Better Anti-Viral Therapy
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Protease | polymer | 99 | 10772.7 | 4 | UniProt (P03369) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 | Retropepsin |
| 2 | B, D | RITONAVIR | non-polymer | 720.9 | 2 | BIRD (PRD_001001) Chemie (RIT) | |||
| 3 | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 99 (UniProt: P03369)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 63 | engineered mutation |
| Asn 25 | Asp 81 | engineered mutation |
| Ala 82 | Val 138 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43090.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1441.9 | |
| All* | Total formula weight | 44532.8 |
