1N3C
Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | DNA complement strand | polymer | 15 | 4635.0 | 1 | |||
| 2 | B (C) | 8-oxoG-containing DNA | polymer | 15 | 4561.9 | 1 | |||
| 3 | C (A) | N-glycosylase/DNA lyase | polymer | 317 | 35647.3 | 1 | UniProt (O15527) Pfam (PF07934) Pfam (PF00730) | Homo sapiens (human) | hOgg1 glycosylase, 8-oxoguanosine DNA glycosylase/DNA-(apurinic or apyrimidinic site) lyase |
| 4 | D (C) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | E, F, G (B, C, A) | water | water | 18.0 | 165 | Chemie (HOH) |
Sequence modifications
A: 12 - 325 (UniProt: O15527)
| PDB | External Database | Details |
|---|---|---|
| Gly 9 | - | cloning artifact |
| Ser 10 | - | cloning artifact |
| Glu 11 | - | cloning artifact |
| Asn 268 | Asp 268 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 44844.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 40.1 | |
| All* | Total formula weight | 44884.4 |
