1MW4
Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Growth factor receptor-bound protein 7 | polymer | 120 | 13690.7 | 1 | UniProt (Q14451) Pfam (PF00017) | Homo sapiens (human) | GRB7 adapter protein, Epidermal growth factor receptor GRB-7, B47 |
| 2 | B (B) | Receptor protein-tyrosine kinase erbB-2 | polymer | 10 | 1266.2 | 1 | UniProt (P04626) | pY1139, NEU proto-oncogene, C-erbB-2, Tyrosine kinase-type cell surface receptor HER2, MLN 19 |
Sequence modifications
A: 3 - 120 (UniProt: Q14451)
B: 1135 - 1144 (UniProt: P04626)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | cloning artifact |
| Ser 2 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Ptr 1139 | Tyr 1139 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 14956.9 | |
| All* | Total formula weight | 14956.9 |
