1MKD
crystal structure of PDE4D catalytic domain and zardaverine complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Phosphodiesterase 4D | polymer | 328 | 37733.7 | 12 | UniProt (Q08499) Pfam (PF00233) | Homo sapiens (human) | cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
| 2 | BA, EA, HA, KA, M... (F, G, H, I, A...) | ZINC ION | non-polymer | 65.4 | 12 | Chemie (ZN) | |||
| 3 | CA, FA, IA, LA, N... (F, G, H, I, A...) | MAGNESIUM ION | non-polymer | 24.3 | 12 | Chemie (MG) | |||
| 4 | AA, DA, GA, JA, MA... (E, F, G, H, I...) | 6-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-2H-PYRIDAZIN-3-ONE | non-polymer | 268.2 | 12 | Chemie (ZAR) | |||
| 5 | AB, BB, CB, DB, EB... (E, F, G, H, I...) | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 183 - 510 (UniProt: Q08499)
| PDB | External Database | Details |
|---|---|---|
| Pro 439 | Arg 644 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 452804.7 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 4295.2 | |
| All* | Total formula weight | 457099.8 |
