1MHW
Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | Cathepsin L | polymer | 175 | 19127.0 | 2 | UniProt (P07711) Pfam (PF00112) | Homo sapiens (human) | Major excreted protein, MEP |
| 2 | B, D (C, D) | Cathepsin L | polymer | 42 | 4783.4 | 2 | UniProt (P07711) | Homo sapiens (human) | Major excreted protein, MEP |
| 3 | E, F, G, H (E, F, G, H) | 4-biphenylacetyl-Cys-(D)Arg-Tyr-N-(2-phenylethyl) amide | polymer | 5 | 739.9 | 4 | BIRD (PRD_000270) | ||
| 4 | I, J, K, L, M... (A, C, B, D, E...) | water | water | 18.0 | 525 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 175 (UniProt: P07711)
| PDB | External Database | Details |
|---|---|---|
| Csd 25 | Cys 138 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 50780.6 | |
| All* | Total formula weight | 50780.6 |
