1M76

Crystal Structure of the S137C Mutant of L-3-HYDROXYACYL-COA Dehydrogenase in Complex with NAD and Acetoacetyl-COA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	3-HYDROXYACYL-COA DEHYDROGENASE	polymer	302	32884.8	2	UniProt (Q16836) Pfam (PF02737) Pfam (PF00725)	Homo sapiens (human)	L-3-HYDROXYACYL-COA DEHYDROGENASE
2	C, E (A, B)	ACETOACETYL-COENZYME A	non-polymer		851.6	2	Chemie (CAA)
3	D, F (A, B)	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	2	Chemie (NAD)
4	G, H (A, B)	water	water		18.0	500	Chemie (HOH)

Sequence modifications

A, B: 1 - 302 (UniProt: Q16836)

PDB	External Database	Details
Cys 137	Ser 149	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65769.6
Non-Polymers*	Number of molecules	4
	Total formula weight	3030.1
All*	Total formula weight	68799.6

*Water molecules are not included.