1LWF

CRYSTAL STRUCTURE OF A MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMQ+M184V: M41L/D67N/K70R/M184V/T215Y) IN COMPLEX WITH NEVIRAPINE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	HIV-1 REVERSE TRANSCRIPTASE	polymer	560	64633.9	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	Human immunodeficiency virus 1	HIV-1 RT
2	B	HIV-1 REVERSE TRANSCRIPTASE	polymer	440	51438.0	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	Human immunodeficiency virus 1	HIV-1 RT
3	A	11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE	non-polymer		266.3	1	Chemie (NVP)
4		water	water		18.0	13	Chemie (HOH)

Sequence modifications

A: 1 - 560 (UniProt: P04585)

PDB	External Database	Details
Leu 41	Met 196	engineered mutation
Asn 67	Asp 222	engineered mutation
Arg 70	Lys 225	engineered mutation
Val 184	Met 339	engineered mutation
Tyr 215	Thr 370	engineered mutation
Csd 280	Cys 435	modified residue

B: 1 - 440 (UniProt: P04585)

PDB	External Database	Details
Leu 41	Met 196	engineered mutation
Asn 67	Asp 222	engineered mutation
Arg 70	Lys 225	engineered mutation
Val 184	Met 339	engineered mutation
Tyr 215	Thr 370	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	116072.0
Non-Polymers*	Number of molecules	1
	Total formula weight	266.3
All*	Total formula weight	116338.3

*Water molecules are not included.