1LWF
CRYSTAL STRUCTURE OF A MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMQ+M184V: M41L/D67N/K70R/M184V/T215Y) IN COMPLEX WITH NEVIRAPINE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HIV-1 REVERSE TRANSCRIPTASE | polymer | 560 | 64633.9 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus 1 | HIV-1 RT |
| 2 | B (B) | HIV-1 REVERSE TRANSCRIPTASE | polymer | 440 | 51438.0 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus 1 | HIV-1 RT |
| 3 | C (A) | 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE | non-polymer | 266.3 | 1 | Chemie (NVP) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
A: 1 - 560 (UniProt: P04585)
B: 1 - 440 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Leu 41 | Met 196 | engineered mutation |
| Asn 67 | Asp 222 | engineered mutation |
| Arg 70 | Lys 225 | engineered mutation |
| Val 184 | Met 339 | engineered mutation |
| Tyr 215 | Thr 370 | engineered mutation |
| Csd 280 | Cys 435 | modified residue |
| PDB | External Database | Details |
|---|---|---|
| Leu 41 | Met 196 | engineered mutation |
| Asn 67 | Asp 222 | engineered mutation |
| Arg 70 | Lys 225 | engineered mutation |
| Val 184 | Met 339 | engineered mutation |
| Tyr 215 | Thr 370 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 116072.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 266.3 | |
| All* | Total formula weight | 116338.3 |
