1KZ8
CRYSTAL STRUCTURE OF PORCINE FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH A NOVEL ALLOSTERIC-SITE INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, F) | FRUCTOSE-1,6-BISPHOSPHATASE | polymer | 337 | 36703.3 | 2 | UniProt (P00636) Pfam (PF00316) Pfam (PF18913) | Sus scrofa (pig) | D-fructose-1,6-bisphosphate 1-phosphohydrolase, FBPase |
| 2 | C, G (A, F) | 6-O-phosphono-beta-D-fructofuranose | non-polymer | 260.1 | 2 | Chemie (F6P) | |||
| 3 | D, H (A, F) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 4 | E, I (A, F) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) | |||
| 5 | F, J (A, F) | {4-[3-(6,7-DIETHOXY-QUINAZOLIN-4-YLAMINO)-PHENYL]-THIAZOL-2-YL}-METHANOL | non-polymer | 422.5 | 2 | Chemie (PFE) | |||
| 6 | K, L (A, F) | water | water | 18.0 | 540 | Chemie (HOH) |
Sequence modifications
A, F: 1 - 337 (UniProt: P00636)
| PDB | External Database | Details |
|---|---|---|
| Gln 20 | Glu 20 | SEE REMARK 999 |
| Thr 96 | Ser 96 | SEE REMARK 999 |
| Asn 199 | Asp 199 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73406.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2169.6 | |
| All* | Total formula weight | 75576.1 |
