1KVL
X-ray Crystal Structure of AmpC S64G Mutant beta-Lactamase in Complex with Substrate and Product Forms of Cephalothin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Beta-lactamase | polymer | 358 | 39557.9 | 2 | UniProt (P00811) Pfam (PF00144) In PDB | Escherichia coli | Cephalosporinase |
| 2 | A | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 3 | A | 2-[CARBOXY-(2-THIOPHEN-2-YL-ACETYLAMINO)-METHYL]-5-METHYL-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID | non-polymer | 356.4 | 1 | Chemie (KCP) | |||
| 4 | A | CEPHALOTHIN | non-polymer | 396.4 | 1 | Chemie (CLS) | |||
| 5 | B | 2-[CARBOXY-(2-THIOPHEN-2-YL-ACETYLAMINO)-METHYL]-5-METHYLENE-5,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID | non-polymer | 354.4 | 1 | Chemie (THN) | |||
| 6 | water | water | 18.0 | 488 | Chemie (HOH) |
Sequence modifications
A, B: 4 - 361 (UniProt: P00811)
| PDB | External Database | Details |
|---|---|---|
| Gly 64 | Ser 80 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 79115.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1297.2 | |
| All* | Total formula weight | 80413.0 |
