1KAE
L-HISTIDINOL DEHYDROGENASE (HISD) STRUCTURE COMPLEXED WITH L-HISTIDINOL (SUBSTRATE), ZINC AND NAD (COFACTOR)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histidinol dehydrogenase | polymer | 434 | 46481.4 | 2 | UniProt (P06988) Pfam (PF00815) | Escherichia coli | HDH |
| 2 | C, D, I, J (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 3 | E, K (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | F (A) | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | non-polymer | 154.3 | 1 | Chemie (DTT) | |||
| 5 | G (A) | L-histidinol | non-polymer | 142.2 | 1 | Chemie (HSO) | |||
| 6 | H, M (A, B) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 2 | Chemie (NAD) | |||
| 7 | L (B) | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 8 | N (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 9 | O, P (A, B) | water | water | 18.0 | 626 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 434 (UniProt: P06988)
| PDB | External Database | Details |
|---|---|---|
| Mse 1 | Met 0 | modified residue |
| Glu 15 | Val 14 | SEE REMARK 999 |
| Mse 22 | Met 21 | modified residue |
| Mse 88 | Met 87 | modified residue |
| Mse 144 | Met 143 | modified residue |
| Ser 150 | Arg 149 | SEE REMARK 999 |
| Mse 232 | Met 231 | modified residue |
| Mse 277 | Met 276 | modified residue |
| Leu 313 | Ser 312 | SEE REMARK 999 |
| Mse 390 | Met 389 | modified residue |
| Leu 403 | Val 402 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 92962.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2299.5 | |
| All* | Total formula weight | 95262.3 |
