1K9M
Co-crystal structure of tylosin bound to the 50S ribosomal subunit of Haloarcula marismortui
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | 23S RRNA | polymer | 2922 | 946034.4 | 1 | GenBank (3377779) | Haloarcula marismortui | |
2 | B | 5S RRNA | polymer | 122 | 39318.4 | 1 | GenBank (3377779) | Haloarcula marismortui | |
3 | C | RIBOSOMAL PROTEIN L2 | polymer | 239 | 25237.5 | 1 | UniProt (P20276) Pfam (PF00181) Pfam (PF03947) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L2P, HMAL2, HL4 |
4 | D | RIBOSOMAL PROTEIN L3 | polymer | 337 | 37265.2 | 1 | UniProt (P20279) Pfam (PF00297) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L3P, HMAL3, HL1 |
5 | E | RIBOSOMAL PROTEIN L4 | polymer | 246 | 26442.1 | 1 | UniProt (P12735) Pfam (PF00573) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L4E, HMAL4, HL6 |
6 | F | RIBOSOMAL PROTEIN L5 | polymer | 176 | 19420.5 | 1 | UniProt (P14124) Pfam (PF00673) Pfam (PF00281) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L5P, HMAL5, HL13 |
7 | G | RIBOSOMAL PROTEIN L6 | polymer | 177 | 19830.5 | 1 | UniProt (P14135) Pfam (PF00347) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L6P, HMAL6, HL10 |
8 | H | RIBOSOMAL PROTEIN L7AE | polymer | 119 | 12600.8 | 1 | UniProt (P12743) Pfam (PF01248) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN HS6 |
9 | I | RIBOSOMAL PROTEIN L10 | polymer | 348 | 37213.8 | 1 | UniProt (P15825) Pfam (PF00466) Pfam (PF17777) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN P0, HMAL10, L10E |
10 | J | RIBOSOMAL PROTEIN L10E | polymer | 167 | 18022.5 | 1 | Pfam (PF00252) UniProt (by SIFTS) (P60617) In PDB | Haloarcula marismortui | |
11 | K | RIBOSOMAL PROTEIN L13 | polymer | 145 | 16249.2 | 1 | UniProt (P29198) Pfam (PF00572) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L13P, HMAL13 |
12 | L | RIBOSOMAL PROTEIN L14 | polymer | 132 | 14216.2 | 1 | UniProt (P22450) Pfam (PF00238) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L14P, HMAL14, HL27 |
13 | M | RIBOSOMAL PROTEIN L15 | polymer | 164 | 17874.2 | 1 | UniProt (P12737) Pfam (PF00828) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L15P, HMAL15, HL9 |
14 | N | RIBOSOMAL PROTEIN L15E | polymer | 194 | 22856.6 | 1 | Pfam (PF00827) UniProt (by SIFTS) (P60618) In PDB | Haloarcula marismortui | |
15 | O | RIBOSOMAL PROTEIN L18 | polymer | 186 | 20509.7 | 1 | UniProt (P14123) Pfam (PF17144) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L18P, HMAL18, HL12 |
16 | P | RIBOSOMAL PROTEIN L18E | polymer | 115 | 12307.7 | 1 | UniProt (P12733) Pfam (PF00828) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L18E, HL29, L19 |
17 | Q | RIBOSOMAL PROTEIN L19E | polymer | 148 | 16631.3 | 1 | UniProt (P14119) Pfam (PF01280) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L19E, HMAL19, HL24 |
18 | R | RIBOSOMAL PROTEIN L21E | polymer | 95 | 10436.6 | 1 | UniProt (P12734) Pfam (PF01157) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L21E, HL31 |
19 | S | RIBOSOMAL PROTEIN L22 | polymer | 154 | 16835.7 | 1 | UniProt (P10970) Pfam (PF00237) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L22P, HMAL22, HL23 |
20 | T | RIBOSOMAL PROTEIN L23 | polymer | 84 | 9481.3 | 1 | UniProt (P12732) Pfam (PF00276) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L23P, HMAL23, HL25, L21 |
21 | U | RIBOSOMAL PROTEIN L24 | polymer | 119 | 13539.8 | 1 | UniProt (P10972) Pfam (PF16906) Pfam (PF00467) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L24P, HMAL24, HL16, HL15 |
22 | V | RIBOSOMAL PROTEIN L24E | polymer | 66 | 7233.7 | 1 | UniProt (P14116) Pfam (PF01246) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L24E, HL21/HL22 |
23 | W | RIBOSOMAL PROTEIN L29 | polymer | 70 | 7758.7 | 1 | UniProt (P10971) Pfam (PF00831) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L29P, HMAL29, HL33 |
24 | X | RIBOSOMAL PROTEIN L30 | polymer | 154 | 17062.9 | 1 | UniProt (P14121) Pfam (PF00327) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L30P, HMAL30, HL20, HL16 |
25 | Y | RIBOSOMAL PROTEIN L31E | polymer | 91 | 10253.4 | 1 | UniProt (P18138) Pfam (PF01198) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L31E, L34, HL30 |
26 | Z | RIBOSOMAL PROTEIN L32E | polymer | 240 | 26324.5 | 1 | UniProt (P12736) Pfam (PF14520) Pfam (PF01655) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L32E, HL5 |
27 | 1 | RIBOSOMAL PROTEIN L37Ae | polymer | 73 | 8097.8 | 1 | Pfam (PF01780) UniProt (by SIFTS) (P60619) In PDB | Haloarcula marismortui | |
28 | 2 | RIBOSOMAL PROTEIN L37E | polymer | 56 | 6199.0 | 1 | UniProt (P32410) Pfam (PF01907) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L37E, L35E |
29 | 3 | RIBOSOMAL PROTEIN L39E | polymer | 48 | 5844.7 | 1 | UniProt (P22452) Pfam (PF00832) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEINS L39E, HL39E, HL46E |
30 | 4 | RIBOSOMAL PROTEIN L44E | polymer | 92 | 10815.2 | 1 | UniProt (P32411) Pfam (PF00935) In PDB | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L44E, LA, HLA |
31 | A | TYLOSIN | non-polymer | 916.1 | 1 | Chemie (TYK) | |||
32 | A, 4, L, B, C... | MAGNESIUM ION | non-polymer | 24.3 | 119 | Chemie (MG) | |||
33 | A, J, K, M, N... | SODIUM ION | non-polymer | 23.0 | 85 | Chemie (NA) | |||
34 | K, 4, A, M, N... | CHLORIDE ION | non-polymer | 35.5 | 22 | Chemie (CL) | |||
35 | A | POTASSIUM ION | non-polymer | 39.1 | 3 | Chemie (K) | |||
36 | 1, 2, 4, P, V | CADMIUM ION | non-polymer | 112.4 | 5 | Chemie (CD) | |||
37 | water | water | 18.0 | 7877 | Chemie (HOH) |
Sequence modifications
A: 2 - 2923 (GenBank: 3377779)
D: 1 - 337 (UniProt: P20279)
Q: 1 - 148 (UniProt: P14119)
3: 1 - 48 (UniProt: P22452)
PDB | External Database | Details |
---|---|---|
C 560 | U 3155 | conflict |
PDB | External Database | Details |
---|---|---|
- | Pro 310 | deletion |
Arg 310 | Phe 311 | conflict |
PDB | External Database | Details |
---|---|---|
Lys 71 | Tyr 71 | conflict |
PDB | External Database | Details |
---|---|---|
- | Arg 31 | deletion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 30 |
Total formula weight | 1451914.1 | |
Non-Polymers* | Number of molecules | 235 |
Total formula weight | 7221.9 | |
All* | Total formula weight | 1459136.0 |