1K73
Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 23S RRNA | polymer | 2922 | 946034.4 | 1 | GenBank (3377779) | Haloarcula marismortui | |
| 2 | B (B) | 5S RRNA | polymer | 122 | 39318.4 | 1 | GenBank (3377779) | Haloarcula marismortui | |
| 3 | C (C) | RIBOSOMAL PROTEIN L2 | polymer | 239 | 25237.5 | 1 | UniProt (P20276) Pfam (PF00181) Pfam (PF03947) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L2P, HMAL2, HL4 |
| 4 | D (D) | RIBOSOMAL PROTEIN L3 | polymer | 337 | 37265.2 | 1 | UniProt (P20279) Pfam (PF00297) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L3P, HMAL3, HL1 |
| 5 | E (E) | RIBOSOMAL PROTEIN L4 | polymer | 246 | 26442.1 | 1 | UniProt (P12735) Pfam (PF00573) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L4E, HMAL4, HL6 |
| 6 | F (F) | RIBOSOMAL PROTEIN L5 | polymer | 176 | 19420.5 | 1 | UniProt (P14124) Pfam (PF00673) Pfam (PF00281) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L5P, HMAL5, HL13 |
| 7 | G (G) | RIBOSOMAL PROTEIN L6 | polymer | 177 | 19830.5 | 1 | UniProt (P14135) Pfam (PF00347) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L6P, HMAL6, HL10 |
| 8 | H (H) | RIBOSOMAL PROTEIN L7AE | polymer | 119 | 12600.8 | 1 | UniProt (P12743) Pfam (PF01248) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN HS6 |
| 9 | I (I) | RIBOSOMAL PROTEIN L10 | polymer | 348 | 37213.8 | 1 | UniProt (P15825) Pfam (PF00466) Pfam (PF17777) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN P0, HMAL10, L10E |
| 10 | J (J) | RIBOSOMAL PROTEIN L10E | polymer | 167 | 18022.5 | 1 | Pfam (PF00252) UniProt (by SIFTS) (P60617) | Haloarcula marismortui | |
| 11 | K (K) | RIBOSOMAL PROTEIN L13 | polymer | 145 | 16249.2 | 1 | UniProt (P29198) Pfam (PF00572) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L13P, HMAL13 |
| 12 | L (L) | RIBOSOMAL PROTEIN L14 | polymer | 132 | 14216.2 | 1 | UniProt (P22450) Pfam (PF00238) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L14P, HMAL14, HL27 |
| 13 | M (M) | RIBOSOMAL PROTEIN L15 | polymer | 164 | 17874.2 | 1 | UniProt (P12737) Pfam (PF00828) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L15P, HMAL15, HL9 |
| 14 | N (N) | RIBOSOMAL PROTEIN L15E | polymer | 194 | 22856.6 | 1 | Pfam (PF00827) UniProt (by SIFTS) (P60618) | Haloarcula marismortui | |
| 15 | O (O) | RIBOSOMAL PROTEIN L18 | polymer | 186 | 20509.7 | 1 | UniProt (P14123) Pfam (PF17144) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L18P, HMAL18, HL12 |
| 16 | P (P) | RIBOSOMAL PROTEIN L18E | polymer | 115 | 12307.7 | 1 | UniProt (P12733) Pfam (PF00828) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L18E, HL29, L19 |
| 17 | Q (Q) | RIBOSOMAL PROTEIN L19E | polymer | 148 | 16631.3 | 1 | UniProt (P14119) Pfam (PF01280) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L19E, HMAL19, HL24 |
| 18 | R (R) | RIBOSOMAL PROTEIN L21E | polymer | 95 | 10436.6 | 1 | UniProt (P12734) Pfam (PF01157) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L21E, HL31 |
| 19 | S (S) | RIBOSOMAL PROTEIN L22 | polymer | 154 | 16835.7 | 1 | UniProt (P10970) Pfam (PF00237) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L22P, HMAL22, HL23 |
| 20 | T (T) | RIBOSOMAL PROTEIN L23 | polymer | 84 | 9481.3 | 1 | UniProt (P12732) Pfam (PF00276) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L23P, HMAL23, HL25, L21 |
| 21 | U (U) | RIBOSOMAL PROTEIN L24 | polymer | 119 | 13539.8 | 1 | UniProt (P10972) Pfam (PF16906) Pfam (PF00467) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L24P, HMAL24, HL16, HL15 |
| 22 | V (V) | RIBOSOMAL PROTEIN L24E | polymer | 66 | 7233.7 | 1 | UniProt (P14116) Pfam (PF01246) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L24E, HL21/HL22 |
| 23 | W (W) | RIBOSOMAL PROTEIN L29 | polymer | 70 | 7758.7 | 1 | UniProt (P10971) Pfam (PF00831) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L29P, HMAL29, HL33 |
| 24 | X (X) | RIBOSOMAL PROTEIN L30 | polymer | 154 | 17062.9 | 1 | UniProt (P14121) Pfam (PF00327) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L30P, HMAL30, HL20, HL16 |
| 25 | Y (Y) | RIBOSOMAL PROTEIN L31E | polymer | 91 | 10253.4 | 1 | UniProt (P18138) Pfam (PF01198) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L31E, L34, HL30 |
| 26 | Z (Z) | RIBOSOMAL PROTEIN L32E | polymer | 240 | 26324.5 | 1 | UniProt (P12736) Pfam (PF14520) Pfam (PF01655) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L32E, HL5 |
| 27 | AA (1) | RIBOSOMAL PROTEIN L37Ae | polymer | 73 | 8097.8 | 1 | Pfam (PF01780) UniProt (by SIFTS) (P60619) | Haloarcula marismortui | |
| 28 | BA (2) | RIBOSOMAL PROTEIN L37E | polymer | 56 | 6199.0 | 1 | UniProt (P32410) Pfam (PF01907) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L37E, L35E |
| 29 | CA (3) | RIBOSOMAL PROTEIN L39E | polymer | 48 | 5844.7 | 1 | UniProt (P22452) Pfam (PF00832) | Haloarcula marismortui | 50S RIBOSOMAL PROTEINS L39E, HL39E, HL46E |
| 30 | DA (4) | RIBOSOMAL PROTEIN L44E | polymer | 92 | 10815.2 | 1 | UniProt (P32411) Pfam (PF00935) | Haloarcula marismortui | 50S RIBOSOMAL PROTEIN L44E, LA, HLA |
| 31 | EA (A) | ANISOMYCIN | non-polymer | 265.3 | 1 | Chemie (ANM) | |||
| 32 | AB, AC, AD, AE, AJ... (A, 4, L, B, C...) | MAGNESIUM ION | non-polymer | 24.3 | 117 | Chemie (MG) | |||
| 33 | KE, LE (A) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 34 | AF, AG, AH, AI, BF... (A, K, M, N, R...) | SODIUM ION | non-polymer | 23.0 | 86 | Chemie (NA) | |||
| 35 | BI, CI, CJ, DI, FH... (K, 4, A, M, N...) | CHLORIDE ION | non-polymer | 35.5 | 22 | Chemie (CL) | |||
| 36 | BJ, KI, VI, YI, ZI (4, P, V, 1, 2) | CADMIUM ION | non-polymer | 112.4 | 5 | Chemie (CD) | |||
| 37 | AK, BK, CK, DJ, DK... (X, Y, Z, A, 1...) | water | water | 18.0 | 7879 | Chemie (HOH) |
Sequence modifications
A: 2 - 2923 (GenBank: 3377779)
D: 1 - 337 (UniProt: P20279)
Q: 1 - 148 (UniProt: P14119)
3: 1 - 48 (UniProt: P22452)
| PDB | External Database | Details |
|---|---|---|
| C 560 | U 3155 | conflict |
| PDB | External Database | Details |
|---|---|---|
| - | Pro 310 | deletion |
| Arg 310 | Phe 311 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Lys 71 | Tyr 71 | conflict |
| PDB | External Database | Details |
|---|---|---|
| - | Arg 31 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 30 |
| Total formula weight | 1451914.1 | |
| Non-Polymers* | Number of molecules | 233 |
| Total formula weight | 6506.3 | |
| All* | Total formula weight | 1458420.5 |
