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1K6C

LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BPOL polyproteinpolymer9910831.82UniProt (P35963)
Pfam (PF00077)
In PDB
Human immunodeficiency virus 1
2A, BACETATE IONnon-polymer59.05Chemie (ACT)
3BN-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDEnon-polymer613.81Chemie (MK1)
4waterwater18.0119Chemie (HOH)
Sequence modifications
A, B: 1 - 99 (UniProt: P35963)
PDBExternal DatabaseDetails
Lys 7Gln 63engineered mutation
Arg 14Lys 70engineered mutation
Thr 82Val 138engineered mutation
Val 84Ile 140engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight21663.5
Non-Polymers*Number of molecules6
Total formula weight909.0
All*Total formula weight22572.5
*Water molecules are not included.

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PDB entries from 2024-07-31

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