1K1T
Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | PROTEASE RETROPEPSIN | polymer | 99 | 10712.6 | 2 | UniProt (P04587) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 | |
| 2 | B | N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide | non-polymer | 833.1 | 1 | BIRD (PRD_000349) Chemie (0Q4) | |||
| 3 | B | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 173 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P04587)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 75 | engineered mutation |
| Ile 33 | Leu 101 | engineered mutation |
| Ile 45 | Lys 113 | engineered mutation |
| Ile 63 | Leu 131 | engineered mutation |
| Ala 67 | Cys 135 | engineered mutation |
| Ser 82 | Val 150 | engineered mutation |
| Ala 95 | Cys 163 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21425.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 929.1 | |
| All* | Total formula weight | 22354.3 |
