1JMO
Crystal Structure of the Heparin Cofactor II-S195A Thrombin Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Thrombin, light chain | polymer | 48 | 5484.0 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | COAGULATION FACTOR II |
| 2 | B (H) | Thrombin, heavy chain | polymer | 260 | 29921.4 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | COAGULATION FACTOR II |
| 3 | C (A) | HEPARIN COFACTOR II | polymer | 480 | 55187.0 | 1 | UniProt (P05546) Pfam (PF00079) | Homo sapiens (human) | HC-II; PROTEASE INHIBITOR LEUSERPIN 2; HLS2; serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 |
| 4 | D (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E (H) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | F, G, J, K, L (H, A) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 5 | Chemie (MPD) | |||
| 7 | H, I (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 8 | M, N, O (L, H, A) | water | water | 18.0 | 208 | Chemie (HOH) |
Sequence modifications
H: 15 - 247 (UniProt: P00734)
A: 1 - 480 (UniProt: P05546)
| PDB | External Database | Details |
|---|---|---|
| Ala 195 | Ser 568 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Tys 60 | Tyr 79 | modified residue |
| Tys 73 | Tyr 92 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 90592.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1056.3 | |
| All* | Total formula weight | 92073.0 |
