1JBP
Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with a Substrate Peptide, ADP and Detergent
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT | polymer | 350 | 40738.3 | 1 | UniProt (P05132) Pfam (PF00069) | Mus musculus (house mouse) | PKA C-ALPHA |
| 2 | B (S) | CAMP-DEPENDENT PROTEIN KINASE INHIBITOR, MUSCLE/BRAIN FORM | polymer | 20 | 2199.4 | 1 | UniProt (P27776) UniProt (by SIFTS) (P61926) | PKI-ALPHA | |
| 3 | C (E) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | D (E) | N-OCTANE | non-polymer | 114.2 | 1 | Chemie (OCT) | |||
| 5 | E, F (E, S) | water | water | 18.0 | 168 | Chemie (HOH) |
Sequence modifications
E: 1 - 350 (UniProt: P05132)
S: 361 - 380 (UniProt: P27776)
| PDB | External Database | Details |
|---|---|---|
| Sep 10 | Ser 10 | modified residue |
| Tpo 197 | Thr 197 | modified residue |
| Glu 242 | Gln 242 | conflict |
| Sep 338 | Ser 338 | modified residue |
| PDB | External Database | Details |
|---|---|---|
| Ala 376 | Asn 20 | engineered mutation |
| Ser 377 | Ala 21 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42937.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 541.4 | |
| All* | Total formula weight | 43479.1 |
