1J8H

Crystal Structure of a Complex of a Human alpha/beta-T cell Receptor, Influenza HA Antigen Peptide, and MHC Class II Molecule, HLA-DR4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN	polymer	181	21084.8	1	UniProt (P01903) Pfam (PF00993) Pfam (PF07654)	Homo sapiens (human)	HLA-DR1, DRA
2	B (B)	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR-4 BETA CHAIN	polymer	192	22506.0	1	UniProt (P13760) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P01911)	Homo sapiens (human)	HLA-DR4, DRB1*0401
3	C (C)	HEMAGGLUTININ HA1 PEPTIDE CHAIN	polymer	13	1506.8	1	UniProt (P03437)	Influenzavirus A
4	D (D)	T-CELL RECEPTOR ALPHA CHAIN	polymer	212	23408.0	1	PIR (RWHUAC) Pfam (PF09291) UniProt (by SIFTS) (P01848)	Homo sapiens (human)	TCR HA1.7 ALPHA CHAIN
5	E (E)	T-CELL RECEPTOR BETA CHAIN	polymer	246	28042.4	1	PIR (S18894) Pfam (PF07654) UniProt (by SIFTS) (P01850)	Homo sapiens (human)	TCR HA1.7 BETA CHAIN
6	F (F)	2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G07375KG)
7	G, H (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
8	I, J, K, L, M (A, B, C, D, E)	water	water		18.0	305	Chemie (HOH)

Sequence modifications

B: 1 - 192 (UniProt: P13760)

PDB	External Database	Details
Val 180	Leu 209	conflict

E: 2 - 251 (PIR: S18894)

PDB	External Database	Details
Ser 192	Cys 207	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	96548.0
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	97414.9

*Water molecules are not included.