1IZ2
Interactions causing the kinetic trap in serpin protein folding
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | alpha1-antitrypsin | polymer | 394 | 44203.1 | 1 | UniProt (P01009) Pfam (PF00079) | Homo sapiens (human) | |
| 2 | B (B) | alpha-D-glucopyranose-(1-2)-(5R)-5-[(2R)-2-hydroxynonyl]-beta-D-xylulofuranose | branched | 454.5 | 1 | In PDB | |||
| 3 | C (A) | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
A: 1 - 394 (UniProt: P01009)
| PDB | External Database | Details |
|---|---|---|
| Leu 51 | Phe 75 | engineered mutation |
| Ala 59 | Thr 83 | engineered mutation |
| Ala 68 | Thr 92 | engineered mutation |
| Gly 70 | Ala 94 | engineered mutation |
| His 101 | Arg 125 | engineered mutation |
| Ala 364 | Val 388 | engineered mutation |
| Ile 374 | Met 398 | engineered mutation |
| Asp 376 | Glu 400 | engineered mutation |
| Ala 381 | Ser 405 | engineered mutation |
| Arg 387 | Lys 411 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 44203.1 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 454.5 | |
| All* | Total formula weight | 44657.6 |
