1I44
CRYSTALLOGRAPHIC STUDIES OF AN ACTIVATION LOOP MUTANT OF THE INSULIN RECEPTOR TYROSINE KINASE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | INSULIN RECEPTOR | polymer | 306 | 34748.8 | 1 | UniProt (P06213) Pfam (PF07714) | Homo sapiens (human) | IR |
| 2 | B (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | C (A) | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) | |||
| 4 | D (A) | water | water | 18.0 | 141 | Chemie (HOH) |
Sequence modifications
A: 978 - 1283 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| Ser 981 | Cys 1008 | engineered mutation |
| Phe 984 | Tyr 1011 | engineered mutation |
| Ala 1161 | Asp 1188 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34748.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 529.5 | |
| All* | Total formula weight | 35278.3 |
