1I3L
MOLECULAR BASIS FOR SEVERE EPIMERASE-DEFICIENCY GALACTOSEMIA: X-RAY STRUCTURE OF THE HUMAN V94M-SUBSTITUTED UDP-GALACTOSE 4-EPIMERASE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | UDP-GLUCOSE 4-EPIMERASE | polymer | 348 | 38384.7 | 2 | UniProt (Q14376) Pfam (PF16363) | Homo sapiens (human) | UDP-GALACTOSE 4-EPIMERASE |
| 2 | C, H (A, B) | GALACTOSE-URIDINE-5'-DIPHOSPHATE | non-polymer | 566.3 | 2 | Chemie (GDU) | |||
| 3 | D, I, J (A, B) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 4 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | F, K (A, B) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 2 | Chemie (NAD) | |||
| 6 | G, L (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 7 | M, N (A, B) | water | water | 18.0 | 935 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 348 (UniProt: Q14376)
| PDB | External Database | Details |
|---|---|---|
| Met 94 | Val 94 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 76769.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2714.3 | |
| All* | Total formula weight | 79483.7 |
