1HSH

CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	HIV-II PROTEASE	polymer	99	10728.3	4	UniProt (P04584) Pfam (PF00077) In PDB	Human immunodeficiency virus 2 (HIV-2)
2	A, C	N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE	non-polymer		613.8	2	Chemie (MK1)
3		water	water		18.0	178	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	42913.3
Non-Polymers*	Number of molecules	2
	Total formula weight	1227.6
All*	Total formula weight	44140.9

*Water molecules are not included.