1HFQ
COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | DIHYDROFOLATE REDUCTASE | polymer | 186 | 21289.4 | 1 | UniProt (P00374) Pfam (PF00186) In PDB | Homo sapiens (human) | DHFR |
2 | A | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
3 | A | N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE | non-polymer | 442.4 | 1 | Chemie (MOT) | |||
4 | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
A: 1 - 186 (UniProt: P00374)
PDB | External Database | Details |
---|---|---|
Ser 31 | Phe 31 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 21289.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1187.8 | |
All* | Total formula weight | 22477.3 |