1HEG
The crystal structures at 2.2 angstroms resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | HIV-1 PROTEASE | polymer | 99 | 10786.7 | 1 | UniProt (P03366) Pfam (PF00077) | Human immunodeficiency virus 1 | |
| 2 | B (E) | methyl N-{(4S,5S)-5-[(L-alanyl-L-alanyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-valyl-L-valinate | non-polymer | 577.7 | 1 | BIRD (PRD_000320) Chemie (PSI) | |||
| 3 | C (E) | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
E: 1 - 99 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Asn 36 | Met 104 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 10786.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 577.7 | |
| All* | Total formula weight | 11364.4 |
