1H3C

Structures of Human Oxidosqualene Cyclase Inhibitors Bound to an Homologous Enzyme

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	SQUALENE--HOPENE CYCLASE	polymer	631	71650.0	3	UniProt (P33247) Pfam (PF00432) Pfam (PF13243)	ALICYCLOBACILLUS ACIDOCALDARIUS	SHC
2	D, F, H (A, B, C)	(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE	non-polymer		306.4	3	Chemie (C8E)
3	E, G, I (A, B, C)	N-(6-{[3-(4-BROMOPHENYL)-1,2-BENZISOTHIAZOL-6-YL]OXY}HEXYL)-N-METHYLPROP-2-EN-1-AMINE	non-polymer		459.4	3	Chemie (R79)
4	J, K, L (A, B, C)	water	water		18.0	191	Chemie (HOH)

Sequence modifications

A, B, C: 1 - 1 (PDB: 1H3C)
A, B, C: 2 - 631 (UniProt: P33247)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	214950.1
Non-Polymers*	Number of molecules	6
	Total formula weight	2297.6
All*	Total formula weight	217247.8

*Water molecules are not included.