1H00
CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | CELL DIVISION PROTEIN KINASE 2 | polymer | 299 | 34002.5 | 1 | UniProt (P24941) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | P33 PROTEIN KINASE |
2 | A | (2S)-1-[4-({6-[(2,6-DIFLUOROPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL | non-polymer | 415.4 | 1 | Chemie (FAP) | |||
3 | A | (2R)-1-[4-({6-[(2,6-DIFLUOROPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL | non-polymer | 415.4 | 1 | Chemie (FCP) | |||
4 | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34002.5 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 830.9 | |
All* | Total formula weight | 34833.4 |