1GXF
CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN COMPLEX WITH THE INHIBITOR QUINACRINE MUSTARD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | TRYPANOTHIONE REDUCTASE (OXIDIZED FORM) | polymer | 492 | 53925.7 | 2 | UniProt (P28593) Pfam (PF07992) Pfam (PF02852) | TRYPANOSOMA CRUZI | N(1), N(8)-BIS(GLUTATHIONYL)SPERMIDINE REDUCTASE |
| 2 | C, G (A, B) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) | |||
| 3 | D (A) | MALEIC ACID | non-polymer | 116.1 | 1 | Chemie (MAE) | |||
| 4 | E, F, H, I (A, B) | QUINACRINE MUSTARD | non-polymer | 468.8 | 4 | Chemie (QUM) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 492 (UniProt: P28593)
| PDB | External Database | Details |
|---|---|---|
| Asn 95 | Lys 95 | variant |
| Asp 112 | Glu 112 | variant |
| His 156 | Asn 156 | variant |
| Thr 353 | Asn 353 | variant |
| Lys 402 | Asn 402 | variant |
| Val 403 | Ile 403 | variant |
| Ile 441 | Val 441 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 107851.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 3562.6 | |
| All* | Total formula weight | 111413.9 |
