1GMN
CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HEPATOCYTE GROWTH FACTOR | polymer | 183 | 21173.3 | 2 | UniProt (P14210) Pfam (PF00024) Pfam (PF00051) | HOMO SAPIENS (HUMAN) | SCATTER FACTOR, SF, HEPATOPOEITIN A |
| 2 | C (C) | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid | branched | 1429.1 | 1 | In PDB GlyTouCan (G93330CR) | |||
| 3 | D, E (A, B) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 2 | Chemie (EPE) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 67 | Chemie (HOH) |
Sequence modifications
A, B: 28 - 210 (UniProt: P14210)
| PDB | External Database | Details |
|---|---|---|
| Val 29 | Ala 29 | engineered mutation |
| Asp 72 | Asn 72 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42346.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1429.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 476.6 | |
| All* | Total formula weight | 44252.3 |
