1GFY
RESIDUE 259 IS A KEY DETERMINANT OF SUBSTRATE SPECIFICITY OF PROTEIN-TYROSINE PHOSPHATASE 1B AND ALPHA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) | polymer | 298 | 34704.5 | 1 | UniProt (P18031) Pfam (PF00102) | Homo sapiens (human) | PTP1B |
| 2 | B (A) | 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]THIOPYRAN-3-CARBOXYLIC ACID | non-polymer | 287.3 | 1 | Chemie (COL) | |||
| 3 | C (A) | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A: 1 - 298 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Val 47 | Arg 47 | engineered mutation |
| Asn 48 | Asp 48 | engineered mutation |
| Thr 151 | Ser 151 | conflict |
| Asp 252 | Glu 252 | conflict |
| Cys 258 | Met 258 | engineered mutation |
| Gln 259 | Gly 259 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34704.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 287.3 | |
| All* | Total formula weight | 34991.9 |
